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1. Biotechnology, generic tools and technologies
| 1.1 High Throughput Research
| Closed (area substantially supported in calls 1-5).
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Focus on:
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Imaging technologies for personalised & individualised medicine applications (“imaging biomarkers” for guiding medical interventions; involvement of end users is encouraged; applications on neurosciences/brain excluded as a dedicated action foreseen under 2.2.1) [SME target 15%].
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| 1.2 Detection, diagnosis and monitoring
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Predictive human safety assessment:
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Identification of key pathways of chronic toxic actions; identification of novel markers of toxicity at molecular,cellular and physiological level (SME target 15%).
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Development of experimental and computational models for quantitative prediction of toxicity (SME target 50%).
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New approaches for safety testing for vaccine development(SME target 30%).
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Systems approaches to characterize adverse immune responses: autoimmune diseases, chronic inflammations, allergies; cancer excluded as a dedicated action is foreseen under 2.4.1. (SME target 30%).
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| 1.3 Suitability, safety and efficacy of medicines
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| 1.4 Innovative therapeutic approaches and interventions
| Closed (in Work Programme 2013).
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2. Translating research for human health
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Focus on:
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Functional validation in cellular and/or animal models of genetic determinants of diseases and ageing processes(large scale phenotyping into model systems/organisms, generation of humanised models, new phenotyping technologies, common ontology, transfer of knowledge)[SME target 15%].
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Metagenomics for Personalised Medicine approaches(exploring and exploiting links between microbiome and chronic diseases by metagenome profiling studies in large cohorts) [SME target 15%].
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| 2.1.1 Large scale data gathering
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| 2.1.2 Systems biology
| Closed (in Work Programme 2013).
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Focus on SMEs involvement and clinical research:
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Prospective data collection and comparative effectiveness research for traumatic brain injury (TBI) – programme level cooperation with US, CAN - towards an International Initiative for TBI Research (InTBIR).
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Imaging tools for diagnosis and monitoring of psychiatric disorders (SME target, 30%).
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Paediatric behavioural disorders characterised by aggressive and/or anti-social traits: from preclinical research to treatment (SME target, 15%).
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Patho-physiology and therapy of epilepsy.
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| 2.2.1 Brain
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| 2.2.2 Human development and ageing
| Closed (in Work Programme 2013, actions related to aging are included under other areas).
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Focus on:
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Innovative vaccines and tools for rapid vaccine production: a.) against pathogens potentially causing drug resistance, and b.) in response to pandemics SBIR-like scheme, SME target, 50%).
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Mapping of drug resistance in developing countries.
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| 2.3.0 Infectious diseases: cross-cutting issues
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Focus on:
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Novel antimicrobials (SME target, 50 %).
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Stratified approaches for pathogen host interactions.
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Support for the JPI AMR (CSA) (possibly included in WP2012 update).
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| 2.3.1 Anti-microbial drug resistance
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| 2.3.2 HIV/AIDS, TB, Malaria
| Closed (in Work Programme 2013).
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Focus on:
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Clinical network for the management of new and emerging epidemics.
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| 2.3.3 New and re-emerging epidemics
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Focus on:
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Clinical development of vaccines for NID of European importance (SME target, 15%).
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Drug development for parasitic diseases (SME target, 15%).
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Novel approaches for the prevention and treatment of respiratory diseases in neonates in low resource setting in developing countries.
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| 2.3.4 Neglected infectious diseases
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Focus on:
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Enhancing patient-centred cancer immunotherapy: tumour-microenvironment, immune evasion, localised versus systemic disease (SME target, 50%)
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Investigator-driven treatment trials for metastatic cancers SME target 15%)
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Clinical trials for supportive and palliative care (SME target 15%)
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| 2.4.1 Cancer
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Focus on:
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Discovery research to reveal novel targets for CVD treatment using available “-omics” knowledge (SME target 30%).
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Comparative effectiveness research of existing imaging detection tools and technologies used for prediction, diagnosis, monitoring and prognosis of CVD.
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| 2.4.2 Cardiovascular diseases
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| 2.4.3 Diabetes and obesity
| Closed (in Work Programme 2013)
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| 2.4.4 Rare diseases
| Closed (in Work Programme 2013)
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| 2.4.5 Other chronic diseases
| Closed (in Work Programme 2013)
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| 3. Optimising the delivery of healthcare
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Focus on:
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Comparative effectiveness research
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Health technology assessments for chronic diseases in the context of the aging population
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| 3.1. Translating clinical research into clinical practice
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| 3.2. Health care systems
| Closed (in Work Programme 2013)
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Focus on:
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Social innovation for health promotion with special attention to physical activity.
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| 3.3. Enhanced health promotion and disease prevention
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| 3.4. International public health research
| Closed (in Work Programme 2013)
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| 4. Actions across the theme
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Priorities:
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SA: Support network for high-technology research performing SMEs (Similar to “fit-for-health” project ending in 2013)
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SA: Impact of legislation on research (Similar to earlier topic)
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SA: Support for presidency events (e.g., events formally linked to EU presidencies in 2013-2014)
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CSA: in support of “Year of Mind and Brain” content to be developed)
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| 4.1 Coordination and support actions across the theme
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Focus on:
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Clinical trials using innovative age-appropriate delivery systems or formulations addressing one of the options below: a.)off-patent medicines for children addressing areas set out in Paediatric Medicines Priority List by EMA [15 % Industry targeted including SMEs], and b.) off patent medicines for the elderly [15 % Industry targeted including SMEs]
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Adverse drug and vaccine reaction research [15 % SME targeted]
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New methodologies for clinical trials in small populations(international cooperation for regulatory science)
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| 4.2. Responding to EU policy needs
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Please, indicate general strategic comments or suggestions concerning the future Health Work Programmes:
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General strategic comments |
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